Metadichol improve liver disease

• Patient with Rheumatoid arthritis with the high levels of RF antibodies, CRP and ESR levels, and low bone mineral density leading to osteoporosis.
• Vitamin D in conjunction with calcium and phosphorus, maintains healthy bones. Increases Vitamin D level has been shown to prevent osteoporotic fractures.
• High levels of vitamin D decrease the risk of autoimmune diseases, and in reducing the risk of rheumatoid arthritis.
• Vitamin D, through its active metabolite 1,25(OH)2D3 controls both innate and adaptive immunity but suppressing the adaptive immunity.
• Vitamin D with its immunomodulatory and anti-inflammatory properties is useful in treating RA patients. Vitamin D inhibits H1 cells and upregulates H2 cells and thus can block autoimmunity.
• TNF is another important cytokine that also has a role in inflammatory diseases such as rheumatoid arthritis (RA) and psoriatic arthritis. Metadichol is TNF-α inhibitors for treatment of RA.
• Metadichol acts on Nuclear Vitamin D receptors (VDR) to stimulate the immune system and inhibit a variety of disease processes, resulting from inflammation to infection.
• Metadichol by its actions on the VDR has affected key biomarkers and mitigated the disease conditions without any side effects.
• Metadichol has successfully lowered both CRP and ESR for the RA patient. RA factor has also decreased rapidly.
• Metadichol treatment led to the lower levels of the important inflammation biomarkers and alleviated pain and increased mobility in RA patients.
• Metadichol has the potential to serve as a novel, safe solution to help patients with RA and other autoimmune diseases that confront the world today.

Metadichol vs Dengue

• Metadichol acts on membrane receptors in cells throughout the body to stimulate the immune system and inhibit a variety of disease processes, including those that result in metabolic diseases such as diabetes, obesity and hypertension.
• Metadichol is safe and effective in controlling blood sugar and HbA1C levels in humans.
• Metadichol has been shown to bind to the vitamin D receptor as an inverse agonist. However, it acts more like a protean agonist ligand to increase or decrease activity depending on the system.
• Metadichol can also act both ways, increasing insulin secretion and reducing insulin in hyperinsulinemia. Therefore, it behaves more like a Protean agonist.
• Since Metadichol has no known negative side effects and consists of natural components of common foods, Metadichol has the potential to serve as a novel treatment for type 2 diabetes.
• Metadichol efficacy in reversing type 1 diabetes. The patient continues to produce insulin 5 years after he stopped using Metadichol.
• Metadichol is useful in both type 1 and 2 diabetes and in modulating insulin levels and reducing sugar levels and thus increasing insulin sensitivity.
• Metadichol binds to VDR and thus an effect on glucose homeostasis that is a hallmark of VDR pathways.
• GPR120 activation can lead to positive effects on type 2 diabetes.
• Metadichol is an agonist of GPR120 (G protein-coupled receptor 120) which has emerged as a key target for metabolic diseases like obesity and insulin resistance.
• Metadichol acts at the nuclear receptor level (VDR) and the transmembrane level (GPR120) and the Cytoplasm and mitochondrial level (inhibition of BCAT1) is probably what makes it such a powerful treatment of choice in diabetes relate diseases.

Metadichol vs Psoriasis & Skin Problems

• Metadichol binds to the vitamin D receptor (VDR) as an inverse agonist.
• Higher levels of Vitamin D are associated with lower levels of C-reactive protein.
• Metadichol acts an inverse agonist but more likely is a Protean agonist. Protean agonists act as both positive and negative agonists on the same receptor depending on the degree of constitutive activity that is present.
• Metadichol increases Vitamin C levels over and beyond what is achieved by oral supplementation.
• Since vitamin C is an antioxidant and reduces C-reactive protein (CRP), a substance that can support the progression of CVD.
• Vitamin C can improve vascular function, reduces blood pressure, and improves vasodilation by increasing Nitric Oxide bioavailability.
• Metadichol can improves the levels of various biomarkers especially Systolic and diastolic blood pressure and markers of CVD like CRP and VLDL.
• Metadichol has a particle size of less than 60nm and has the potential to serve as an anti-hypertensive and anti-inflammatory molecule.

Metadichol vs Asthma

• Metadichol has demonstrated no toxicity at doses of up to 5000 mg/kg.
• Metadichol can displace viruses bound to it and block viral entry into the host cells.
• Metadichol could serve as a preventive agent for Zika given that it strengthens the innate immunity through VDR binding.
• Metadichol is a safe and effective inhibitor for enveloped viruses in humans. Since it is known to bind to the vitamin D receptor (VDR), its action mechanism likely involves the competitive displacement of virus particles from VDR's on host cell membranes.
• Cell culture experiments supported the hypothesis that vitamin D has direct antiviral effects, particularly against enveloped viruses. The antiviral mechanism of vitamin D may be due to the ability of vitamin D to up regulate the antimicrobial peptides LL-37 (cathelicidin) and human beta-defensin (epithelial cell derived antimicrobial peptides (AMPs) that protect mucosal membranes from microbial challenges).
• By binding to the VDR (which is a key receptor for innate immunity and is present in all cells), Metadichol can displace viruses bound to it and block viral entry into the host cells. The fact that Metadichol has inhibitory effects against many viruses suggests that viral binding to the VDR does occur and that Metadichol competitively disrupts this process.

Metadichol vs Corona Viruses

• Vitamin C levels can be low in patients with hyperthyroidism.
• This cluster of six genes (TNF, ICAM1, CCL2, VDR, THRA, THRB) target all the thyroid related diseases.
• Metadichol is an inverse agonist of THRA (Thyroid Receptor Alpha) and THRB (Thyroid Receptor Beta). The thyroid hormone receptors, THRA and THRB are members of the nuclear receptor family.
• Hypothyroidism is a disorder with multiple causes in which the thyroid fails to secrete an adequate amount of thyroid hormone. Hyperthyroidism results in excess synthesis and secretion of thyroid hormones by the thyroid gland.
• Hashimoto's is an autoimmune disease, meaning that the immune system inappropriately attacks your thyroid gland. Thyroid-attacking antibodies produced are Thyroid Peroxidase antibodies (TPO) and Thyroglobulin Antibodies (TgAb). Hashimoto disease leads to conditions that cause inflammation and gradual destruction of thyroid gland over time leading to hypothyroidism.
• Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactive thyroid. This is caused by overstimulation of the thyroid. Graves' disease leads to goiter and in some cases thyroid nodules. This leads to cancer of the thyroids that is most often found in nodules in the thyroid gland.
• Metadichol binds to thyroid nuclear receptors of both THRA and THRB but as an inverse agonist.
• Metadichol is also an inverse agonist of other nuclear receptors VDR, AHR (Aryl hydrocarbon receptor) and RORC (RAR related Orphan receptor C).
• Metadichol binding to thyroid nuclear receptors leads to control of TSH and also T3 and T4 levels.
• Metadichol is behaving as a protean agonist. Metadichol is effective against both hyperthyroidism and hypothyroidism and normalizing T3, T4 and levels of antiobodies.
• Binding to vitamin D receptor for example is known to affect over 2900 genes.
• Genes DIO 1, 2 and 3 play a role in maintaining appropriate levels of T3 and T4 in regulating the thyroid hormone pathway.
• Compared to drugs uses in treating diseases Metadichol is a safe and effective nutraceutical to mitigate Thyroid related diseases.

Metadichol vs Longevity (by inhibiting BCAT1 Gene)

• The high red cell distribution width (RDW) levels are an indication of increased oxidative stress and can be seen in kidney diseases.
• High RDW levels are associated with an increased risk of adverse outcomes in patients with severe sepsis, heart failure, coronary artery disease, stroke, and acute kidney injury that required renal replacement therapy and kidney transplant.
• Accelerating RBC destruction and ineffective erythropoiesis are common in patients undergoing dialysis, and bone marrow dysfunction which leads to a high RDW level.
• High level of RDW impairs iron metabolism, and the resulting inflammation disrupts the process of erythropoiesis.
• Pro-inflammatory cytokines like TNF-α are well known to inhibit RBC maturation and proliferation. This results in the production of ineffective red blood cells and elevated RDW.
• Metadichol binds to VDR and is also a TNF-α inhibitor to reduce inflammatory cytokines and bring about the normalization of RDW, Red blood cell, and haeomoglobin levels.
• Metadichol shown improvements of Creatinine, Iron, PTH in patients with CKD and high RDW levels.
• Metadichol help to reduce water retention in legs, physical strength, blood pressure, blood glucose level, and general feeling of wellness with no side effects.