Metadichol improve liver disease
Metadichol improve liver disease
- Vitamin D levels are low in most patients with liver diseases
- The liver has a central role in vitamin D synthesis
- Metadichol can inhibits the chemokines are known to have important role in liver diseases such as TNF-α, ICAM1, CCL2 and PAI1.
- Metadichol indeed does work in liver disease patients by normalizing essential liver enzymes ALT, AST and ALP, and GGT.
- Vitamin D supplementation can help patients with liver diseases.
- Serum levels of TNF-α is directly related to the severity of hepatic dysfunction in liver Cirrhosis. TNF-α enhances HSC (Hepatic stellate cells) survival leading to enhanced liver fibrosis.
- Patients with chronic HCV-related hepatitis have higher levels of sICAM-1
- Increase in sICAM-1 level is a result of HCV activity, which damages both hepatocytes, sinusoidal vessels and endothelial cell.
- In liver diseases CCL2 and CCR2 levels are high and results in increased inflammation, fibrosis, and steatosis.
- PAI-1 has a major role in mediating fibrosis during cholestasis.
- Hepatic steatosis can be blocked by inhibiting PAI-1 activation.
- Metadichol binding to VDR and inhibition of TNF, ICAM1, CCL2 and PAI-1.
Metadichol vs Rheumatoid Arthritis & Osteoporosis
- Patient with Rheumatoid arthritis with the high levels of RF antibodies, CRP and ESR levels, and low bone mineral density leading to osteoporosis.
- Vitamin D in conjunction with calcium and phosphorus, maintains healthy bones. Increases Vitamin D level has been shown to prevent osteoporotic fractures.
- High levels of vitamin D decrease the risk of autoimmune diseases, and in reducing the risk of rheumatoid arthritis.
- Vitamin D, through its active metabolite 1,25(OH)2D3 controls both innate and adaptive immunity but suppressing the adaptive immunity.
- Vitamin D with its immunomodulatory and anti-inflammatory properties is useful in treating RA patients. Vitamin D inhibits H1 cells and upregulates H2 cells and thus can block autoimmunity.
- TNF is another important cytokine that also has a role in inflammatory diseases such as rheumatoid arthritis (RA) and psoriatic arthritis. Metadichol is TNF-α inhibitors for treatment of RA.
- Metadichol acts on Nuclear Vitamin D receptors (VDR) to stimulate the immune system and inhibit a variety of disease processes, resulting from inflammation to infection.
- Metadichol by its actions on the VDR has affected key biomarkers and mitigated the disease conditions without any side effects.
- Metadichol has successfully lowered both CRP and ESR for the RA patient. RA factor has also decreased rapidly.
- Metadichol treatment led to the lower levels of the important inflammation biomarkers and alleviated pain and increased mobility in RA patients.
- Metadichol has the potential to serve as a novel, safe solution to help patients with RA and other autoimmune diseases that confront the world today.
Metadichol vs Rheumatoid Arthritis & Osteoporosis
Metadichol vs Dengue
Metadichol vs Dengue
- Metadichol was seen to improve platelet count in some patients.
- Dengue patients fully recovered from dengue within a few days of taking Metadichol.
- Metadichol helped to reverse platelets declining trend, improve platelet & white blood cells to normal level within a few days.
- Vitamin D deficiency increases the risks for Dengue, vitamin D has direct anti-viral effect against enveloped viruses.
- The antiviral mechanism of vitamin D may be due to the ability of vitamin D to up regulate the antimicrobial peptides LL-37 (cathelicidin) and human beta-defensin.
- Metadichol has inhibitory effects against many viruses by displace viruses bound to it and block viral entry into host cells.
Metadichol vs Diabetes
- Metadichol acts on membrane receptors in cells throughout the body to stimulate the immune system and inhibit a variety of disease processes, including those that result in metabolic diseases such as diabetes, obesity and hypertension.
- Metadichol is safe and effective in controlling blood sugar and HbA1C levels in humans.
- Metadichol has been shown to bind to the vitamin D receptor as an inverse agonist. However, it acts more like a protean agonist ligand to increase or decrease activity depending on the system.
- Metadichol can also act both ways, increasing insulin secretion and reducing insulin in hyperinsulinemia. Therefore, it behaves more like a Protean agonist.
- Since Metadichol has no known negative side effects and consists of natural components of common foods, Metadichol has the potential to serve as a novel treatment for type 2 diabetes.
- Metadichol efficacy in reversing type 1 diabetes. The patient continues to produce insulin 5 years after he stopped using Metadichol.
- Metadichol is useful in both type 1 and 2 diabetes and in modulating insulin levels and reducing sugar levels and thus increasing insulin sensitivity.
- Metadichol binds to VDR and thus an effect on glucose homeostasis that is a hallmark of VDR pathways.
- GPR120 activation can lead to positive effects on type 2 diabetes.
- Metadichol is an agonist of GPR120 (G protein-coupled receptor 120) which has emerged as a key target for metabolic diseases like obesity and insulin resistance.
- Metadichol acts at the nuclear receptor level (VDR) and the transmembrane level (GPR120) and the Cytoplasm and mitochondrial level (inhibition of BCAT1) is probably what makes it such a powerful treatment of choice in diabetes relate diseases.
Metadichol vs Diabetes
Metadichol vs Psoriasis & Skin Problems
Metadichol vs Psoriasis & Skin Problems
- Metadichol is an innovative treatment or treating multiple skin diseases like eczema, acne, diabetic wounds, viral & bacterial infection and also improving skin texture. Metadichol is a safe, non-toxic, low-cost solution that combating over 3000 skin diseases.
- There is a common pathway through which Metadichol acts to mitigate the condition such as eczema or viral skin disease like herpes or diabetic wound healing and skin rejuvenation.
- Metadichol is an inverse agonist of vitamin D receptor (VDR), aryl hydrocarbon receptor (AHR), and ROR gamma (RORC) that could have beneficial effects on skin diseases.
- Metadichol modulating Th1 pathway towards TH2, Th 17, IL 17, IL22 and also being a TNF-α inhibitor,can modulate IL23 thus blocking the major pathways that caused many skin diseases.
- Treated with vitamin D led to decreased severity of the skin disease & wound healing.
- Skin wounds require vitamin D3 to protect against infections to initiate the normal repair process. Vitamin D has an indirect role in wound healing due to its effect on improved glycemic control in 12 weeks among patients with diabetic foot injury and reduced inflammatory markers like ESR, hS-CRP.
- Metadichol is an inhibitor of TNF-α a significant cytokine of inflammatory diseases of the skin.
- Metadichol increases Vitamin C levels over and beyond what is achieved by oral supplementation. Vitamin C has antioxidant, anti-inflammatory, photoprotective properties, and is a known bio stimulator of collagen synthesis. It has a role in the maintenance of dermal collagen, preventing the inactivation of enzymes involved in the biosynthesis of collagen, hydroxylase, and lysine.
- Metadichol is the first molecule to successfully navigate around the problems involved with promiscuous ligands and targets. It fulfills the goals of the emerging field of polypharmacology i.e., a single drug is able to bind to multiple targets beyond the one drug, one target philosophy.
Metadichol vs Hypertension
- Metadichol binds to the vitamin D receptor (VDR) as an inverse agonist.
- Higher levels of Vitamin D are associated with lower levels of C-reactive protein.
- Metadichol acts an inverse agonist but more likely is a Protean agonist. Protean agonists act as both positive and negative agonists on the same receptor depending on the degree of constitutive activity that is present.
- Metadichol increases Vitamin C levels over and beyond what is achieved by oral supplementation.
- Since vitamin C is an antioxidant and reduces C-reactive protein (CRP), a substance that can support the progression of CVD.
- Vitamin C can improve vascular function, reduces blood pressure, and improves vasodilation by increasing Nitric Oxide bioavailability.
- Metadichol can improves the levels of various biomarkers especially Systolic and diastolic blood pressure and markers of CVD like CRP and VLDL.
- Metadichol has a particle size of less than 60nm and has the potential to serve as an anti-hypertensive and anti-inflammatory molecule.
Metadichol vs Hypertension
Metadichol vs Asthma
Metadichol vs Asthma
- Asthma leads to inflammation of the airways.
- Oxidants are one of the important factors that damage the airways. Low levels of antioxidants lead to more severe asthma.
- Vitamin C is a protective antioxidant of the airways and decreasing airway eosinophils in asthma is an indicator improved asthmatic conditions.
- Asthma has many potential molecular targets including cytokines, chemokines, transcription factors, tyrosine kinases, and receptors.
- Metadichol reducing allergic pulmonary inflammation and decreasing the eosinophils and inflammatory cytokines.
- Metadichol has a particle size of less than 60nm can passes through the bronchial tract and directly reach the lungs and act on the site of injury in asthma.
- Metadichol binds to Vitamin D receptor (VDR) that is responsible for enhancing immunity, which is present in almost all organs and tissues of the body, and by improving immunity it helps the body heal itself.
Metadichol vs Zika
- Metadichol has demonstrated no toxicity at doses of up to 5000 mg/kg.
- Metadichol can displace viruses bound to it and block viral entry into the host cells.
- Metadichol could serve as a preventive agent for Zika given that it strengthens the innate immunity through VDR binding.
- Metadichol is a safe and effective inhibitor for enveloped viruses in humans. Since it is known to bind to the vitamin D receptor (VDR), its action mechanism likely involves the competitive displacement of virus particles from VDR's on host cell membranes.
- Cell culture experiments supported the hypothesis that vitamin D has direct antiviral effects, particularly against enveloped viruses. The antiviral mechanism of vitamin D may be due to the ability of vitamin D to up regulate the antimicrobial peptides LL-37 (cathelicidin) and human beta-defensin (epithelial cell derived antimicrobial peptides (AMPs) that protect mucosal membranes from microbial challenges).
- By binding to the VDR (which is a key receptor for innate immunity and is present in all cells), Metadichol can displace viruses bound to it and block viral entry into the host cells. The fact that Metadichol has inhibitory effects against many viruses suggests that viral binding to the VDR does occur and that Metadichol competitively disrupts this process.
Metadichol vs Zika
Metadichol vs Corona Viruses
Metadichol vs Corona Viruses
- SARS-COV-2 has reaffirmed the importance of interactions between components of the host cell plasma membrane and the virus envelope as a critical mechanism of infection.
- Long-chain saturated lipid alcohols, reduce the infectivity of various types of viruses, including coronaviruses by modifying lipid-dependent attachment to human host cells.
- SARS-COV-2 uses the receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming.
- Metadichol is 270 times more potent than inhibitor camostat mesylate to inhibit TMPRSS2.Metadichol is also an inhibitor of ACE2.
- Viral envelope lipids play a role in both viral stability and infective capabilities.
- Metadichol was tested for its inhibitory actions against ACE2 and TMPRSS2 and in an antiviral assay with SARS-COV-2.
- Metadichol acts as an immunomodulatory and viral inhibitor that competes with viral particles to bind with vitamin D receptors and hence it can prevent virus entry into host cells.
- Metadichol inhibits SARS-COV-2 entry into host cells by inhibiting TMPRSS2 and partial inhibition of ACE2 and boosts the antiviral response by enhancing innate and adaptive immunity through the vitamin D pathway and antiviral activity by endogenously increasing vitamin C levels.
- Metadichol boost innate and adaptive immunity through Vitamin D pathway and recycle vitamin C. The telomere lengthening function helps to maintain naive T and B cells level. (Naive T and B cells are particularly important when our bodies encounter new pathogens, such as SARS-COV-2. The quantity of these cells is crucial for useful immune function).
- Metadichol modulates cytokine storms, as it is an inhibitor of TNF, ICAM1 and CCL2.
- Signalling via AHR may dampen the immune response against coronavirus. Metadichol binds to AHR as an inverse/protean agonist and thus can reduce complications attributed to uncontrolled inflammation and cytokine storms.
- Metadichol control Co-morbidities of Covid19 patients, such as hypertension and diabetes, to prevent long-term prognosis for the affected patients.
- Vitamin C as a crucial player in various aspects of immune cell functions, such as immune cell proliferation and differentiation, in addition to its anti-inflammatory properties.
- Metadichol increases Vitamin C levels over and beyond what is achieved by oral supplementation.
Metadichol vs Thyroid
- Vitamin C levels can be low in patients with hyperthyroidism.
- This cluster of six genes (TNF, ICAM1, CCL2, VDR, THRA, THRB) target all the thyroid related diseases.
- Metadichol is an inverse agonist of THRA (Thyroid Receptor Alpha) and THRB (Thyroid Receptor Beta). The thyroid hormone receptors, THRA and THRB are members of the nuclear receptor family.
- Hypothyroidism is a disorder with multiple causes in which the thyroid fails to secrete an adequate amount of thyroid hormone. Hyperthyroidism results in excess synthesis and secretion of thyroid hormones by the thyroid gland.
- Hashimoto's is an autoimmune disease, meaning that the immune system inappropriately attacks your thyroid gland. Thyroid-attacking antibodies produced are Thyroid Peroxidase antibodies (TPO) and Thyroglobulin Antibodies (TgAb). Hashimoto disease leads to conditions that cause inflammation and gradual destruction of thyroid gland over time leading to hypothyroidism.
- Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactive thyroid. This is caused by overstimulation of the thyroid. Graves' disease leads to goiter and in some cases thyroid nodules. This leads to cancer of the thyroids that is most often found in nodules in the thyroid gland.
- Metadichol binds to thyroid nuclear receptors of both THRA and THRB but as an inverse agonist.
- Metadichol is also an inverse agonist of other nuclear receptors VDR, AHR (Aryl hydrocarbon receptor) and RORC (RAR related Orphan receptor C).
- Metadichol binding to thyroid nuclear receptors leads to control of TSH and also T3 and T4 levels.
- Metadichol is behaving as a protean agonist. Metadichol is effective against both hyperthyroidism and hypothyroidism and normalizing T3, T4 and levels of antiobodies.
- Binding to vitamin D receptor for example is known to affect over 2900 genes.
- Genes DIO 1, 2 and 3 play a role in maintaining appropriate levels of T3 and T4 in regulating the thyroid hormone pathway.
- Compared to drugs uses in treating diseases Metadichol is a safe and effective nutraceutical to mitigate Thyroid related diseases.
Metadichol vs Thyroid
Metadichol vs Longevity (by inhibiting BCAT1 Gene)
Metadichol vs Longevity (by inhibiting BCAT1 Gene)
- BCAT1 has been linked to various diseases in aging and pathological states, including accelerated growth of malignant gliomas, decreased sepsis survival and increased accumulation of liver fat, the latter being linked to a number of metabolic diseases. Consistently, systemic disruption of one BCAT iso-form, namely BCATm, in mice increases energy expenditure and reduces body weight and cancer.
- Blocking of BCAT 1 gene increased the lifespan by nearly 25%. When this gene is blocked, the amino acid chains accumulated in the tissue triggering longevity in the nematodes.
- Health and longevity of the nematodes improved when BCAT 1 was inhibited. Gabapentin has been shown to inhibit BCAT 1. Metadichol inhibits BCAT1 3000 times more potent than Gabapentin.
- BCAT1 overexpression is associated with advanced tumor status
- Overexpression of BCAT1 induces cell proliferation, migration, and invasion in nasopharyngeal carcinoma patients.
- Vitamin D has a role in the down-regulation of BCAT1.Metadichol binds to the vitamin D receptor (VDR) as an inverse agonist and inhibitor of BCAT1.
Metadichol vs Chronic Kidney Disease (CKD)
- The high red cell distribution width (RDW) levels are an indication of increased oxidative stress and can be seen in kidney diseases.
- High RDW levels are associated with an increased risk of adverse outcomes in patients with severe sepsis, heart failure, coronary artery disease, stroke, and acute kidney injury that required renal replacement therapy and kidney transplant.
- Accelerating RBC destruction and ineffective erythropoiesis are common in patients undergoing dialysis, and bone marrow dysfunction which leads to a high RDW level.
- High level of RDW impairs iron metabolism, and the resulting inflammation disrupts the process of erythropoiesis.
- Pro-inflammatory cytokines like TNF-α are well known to inhibit RBC maturation and proliferation. This results in the production of ineffective red blood cells and elevated RDW.
- Metadichol binds to VDR and is also a TNF-α inhibitor to reduce inflammatory cytokines and bring about the normalization of RDW, Red blood cell, and haeomoglobin levels.
- Metadichol shown improvements of Creatinine, Iron, PTH in patients with CKD and high RDW levels.
- Metadichol help to reduce water retention in legs, physical strength, blood pressure, blood glucose level, and general feeling of wellness with no side effects.
Metadichol vs Chronic Kidney Disease (CKD)